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  • 12/26/25 Medetomidine Provider Advisory from Jefferson County Public Health

    Summary: What is Medetomidine? Similar to xylazine, medetomidine is a synthetic alpha-2 agonist sedative used in veterinary medicine. In human medicine, medetomidine is most similar to dexmedetomidine (Precedex®) and clonidine. Overdoses involving medetomidine are associated with prolonged sedation that requires adapting overdose response protocols to prioritize breathing over responsiveness. Medetomidine can produce a severe withdrawal…