Be aware, providers have reported COVID-19 rebound—recurring symptoms or a new positive test after a negative test—2–8 days after initial recovery. A brief return of symptoms may be part of SARS-CoV-2 infection in some people, regardless of treatment or vaccination status. Case reports suggest patients with COVID-19 rebound who were treated with Paxlovid have mild illness.
Do not offer retreatment. Evidence does not indicate additional treatment is needed.
Tell patients with COVID-19 rebound to isolate per CDC guidance and take additional precautions to prevent transmission.